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Pharmaceutical name: Radix Tripterygium wilfordii
Latin botanical name: Tripterygium wilfordii Hook. f.
Common Name: three-wing-nut
Folk Name: "Walk Seven Steps and Die," "Intestine Breaking Plant"
Properties (characteristics) bitter and very toxic
Actions & Indications:
for: anti-inflammation, kills worms, resolves toxin, treating proteinuric renal disease, using as immunosuppressive agent on autoimmune diseases.
Chemical ingredients:
1. Saponins:
(1). wilforgine, wilforgine-B, wilfordine, wilfornine, wilfortrine, wilforttrine-D, wilforzine[1-3], wilformine [4], wilfordinic acid, hyudroxywilfordie acid [5],wilfornine [6], neowilforine [7]
(2). celacinnine, celafurine, celabenzine, celallocinnine [8-9]
(3). triptofordinine A-1, A-2 [10], triptofordin D-1, D-2, E [11], triptofordin A, B, C-1 C-2 [12], triptofordin F-1, F-2, F-3, F-4 [13]
2.
(1). triptolide, tripdiolide, triptonide,[14-15], tripterolide[16].
(2). triptolidenol [16-17], tripnolide [18], neotriptophenolide, triptophenolide methyl ether [19], isoneotrip-tophenolide, hypolide methyl ether [20].
(3). triptonoterpene, triptonoterpene methyl ether [17], triptonoterpenol [21]12-ydroxy-abieta-8, 11, 13 -trien-3-one, 11-hydroxy-14-methoxy-abieta-8, 11-hydroxy-14-methoxy-abieta-8, 11, 13-trien-3-one [22].
3. (1). wilforlide A, wilforlide B [23].
(2). tritotriterpenoid lactone [24], tretotriterpenic acid A [25,26], tritotriterpenic acid B [27], tritotriterpenic acid C [28], 3-epikatonic acid [29], polpunonic acid, triptodihydroxy acid methyl ester [30], tripterine [31].
(3).3,24-dioxofridelan-29-oic acid [29], salaspermic acid [29,32].
4. wilfornide [20]
5. 1,8-dihydroxy-4-hydroxymethyl anthraquinone [33].
6. syringareisnol [34].
7. dulcitol, glucose [31], tannin
Medical Functions:
1. Effects on immune system
2. Effects on anti-inflammatory
3. Effects on anti-cancer
4. Effects on contraception
5. Effects on urinary system
6. Effects on anti-organism and worms
7. Other Effects
Anti rejection on transplants
8. Inside body
9. Effects of toxicity
Other Research:
Four compounds purified from T. wilfordii may confer protection against the FSGS (focalsegmental gomerulosclerosis) factor.a
Research on Pharmacological Processes:
Modern Clinical Application: 1.proliferative arthritis
2. inflammation of spinal cord
3. lupus
4. purpura
5. kidney inflammation
6. asthma
7. tuberculosis of the lungs
8. psoriasis
9. dermatitis
10. Reiter syndrome
Toxicity and Side Effects:
1. Toxic reactions: dizziness, palpitation, weakness, nausea, vomiting, stomach ache, diarrhea, pain in liver and kidney areas, bleeding in the digestive tract, even respiration and circulation exhaustion and death.
2. Decrease of total blood cell counts (2)
3. Mutation type of illness: using lei gong teng tincture for external use can cause mutation type of illness. (3)
4. Long -term use of lei gong teng could significantly decrease bone mineral density of levels in female systemic lupus erythematosus (SLE)b
5. Long -term use of lei gong teng causes hair loss and malfunction of immune system.
antidotes: Prevention and treatments
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